Gene expression is affected not only by nucleotide sequence, but also by DNA folding


Dutch researchers from Leiden University have found that how our DNA is folded is a programmed command present in our genes, and the command varies from life-form to life-form instead of following a generic standard. While traditionally we may think that genetic information is only present in the way that the DNA molecules G-A-T-C are combined, prevalent research shows that the way in which the molecules are bound into coils expose the outer molecules of the coil to express themselves while leaving the inner molecules as latent in expression.