The term ‘hack’ evokes varied meanings. Some consider hacking as a sign of technical virtuosity, for some it is a ‘dirty’ word and to some it means danger and illicit activity. So what does it signify? A hacker in the classic sense of the term is someone who has a strong interest in understanding how ‘things’ work at a fundamental level and also enjoys modifying them or tinkering with them as a hobby or for convenience purposes.In the past decade, a new group of science tinkerers and risk takers known as Do-It-Yourself scientists or biohackers have arrived on the scene! These biohackers want to understanding how the biological processes/microbes/life manifests so that they can tinker and innovate. They want to apply the idea of hacking to cells and organisms!