Stem cell scientists reprogram commonly found cell into master heart cell

Induced cardiac progenitor cells (iCPCs) injected into hearts of mice with experimentally induced heart attacks generate new heart muscle. Credit: Pratik Lalit

Induced cardiac progenitor cells (iCPCs) injected into hearts of mice with experimentally induced heart attacks generate new heart muscle. Credit: Pratik Lalit

Researchers at the University of Wisconsin-Madison led by cardiologist Timothy J. Kamp have genetically reprogrammed the most common type of cell found in mammalian connective tissue called fibroblasts into primitive master heart cells known as induced cardiac progenitor cells- from which the developing heart originates. Published in the journal Cell Stem Cell, the team says the technology could permit a scalable method for making an almost unlimited supply of the three major types of cells in the heart.

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