Cancer cells reprogrammed back to normal: PLEKHA7 stops tumor progression


Over many years cancer cells have had the upper hand in fully establishing the deadly disease due to their ability to proliferate to a state of immortality. For the first time, scientists from the Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center have made a breakthrough in understanding how brakes can be applied to stop the proliferation of tumor cells and restoring them to a benign state. E-Cadherin and p120 are the two important proteins involved in the growth and proliferation of epithelial cells, these are principally the cells which evolve into the blood vessels, organs and various parts of the body. Normal cells form contacts with each other forming junctions when proliferation stops, cancer cells lack this ability and continue their monstrous growth.