Chronic typhoid fever provokes Gall bladder carcinoma transformation


An international joint research group, based in the Netherlands Cancer Institute, has recently identified Salmonella typhi as a risk factor that contributes to cellular transformation in gallbladder carcinomas. Although viral infections have been well connected to a variety of cancers, bacteria are largely ignored as direct contributors to cancer development; as they fail to integrate their DNA into the host genome. However, in some rare cases bacteria can lead to tumor formation. For instance, Helicobacter pylori and Mycobacterium tuberculosis are linked to gastric cancer and lung cancer, respectively.