A step closer towards treatment of Myocardial Infarction and Heart Failure


Myocardial infarction is primarily an irreversible necrosis of cardiac muscles that occurs in response to ischemia/reperfusion (I/R)-induced injury. The I/R-induced injury happens when the blood supply returns back to the tissue after a peroid of deprivation or anoxia, causing an oxidative stress that triggers autophagy-related pathways. Earlier experiments have identified ATG7 as a key autophagy promoting gene, which gets wired up in I/R-induced myocardial injury. A recent research has shed some light on ATG7 regulation in I/R-induced myocardial infarction. The researchers found that ATG7 is regulated through the interaction with both micro-RNA and long non-coding RNA.