Evidence for human transmission of Alzheimer’s pathology


Prions are misfolded proteins that trigger misfolding and aggregation of normal proteins and are responsible for some rare diseases such as the mad cow disease in cattle and Creutzfeldt-Jakob disease (CJD) in humans. A study led by Zane Jaunmuktane and John Collinge explored the possibility of human to human transmission of Alzheimer’s pathology. This pioneering work first explores the possibility of human transmission of pathological proteins.